Kindly help me to design a bioinformatics methodology for the list of frame shift mutation associated with a specific disease. These variant are found in a protein which has disorder regions. Can I analyze the structural effect influenced by these frame-shift variant in a protein?
Thanks for the articles. They were really useful. Most specifically article by Rausell et al.
Once again thanks for your support.
You can look for the gain or loss of functional motifs as a result of the frame-shift. For this, the ELM server (http://elm.eu.org/) can be used. You should provide the protein sequence of the mutated and unmutated protein if the frame shift is within a protein coding gene.
Thank you@Padhmanand Sudhakar for your answer. I have several variants in the coding regions. I will try ELM server.
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