As a Pharmacist, which resource do you use to check whether the Excipients are safe for your patients or not? I have read in some references that Saccharin is hepatotoxic, and when I checked "Handbook of Pharmaceutical Excipients, Sixth Edition", I found nothing about that! So, can you help me with this dilemma?
In my knowledge, it's quite difficult to figure out the safety data of an OLD excipients. Some toxicological information in the MSDS (material safety data sheet) of excipient could be helpful (but not too much). For example, this is MSDS of Polysorbate 80: http://www.sciencelab.com/msds.php?msdsId=9926645.
About a new excipient, because of legal requirement, the safety evidence should be available. You need to contact to the manufacturer for more information.
For excipients used in pediatrics see the Safety and Toxicity of Excipients for Paediatrics (STEP) database provided by the European Pediatric Formulation Initiative (EUPFI)
https://step-db.ucl.ac.uk/eupfi/appDirectLink.do?appFlag=login
Best regards
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