I am buying a high resolution MS, and wondering which one to buy between these two, or other similar-level options.
It's not just a case of which is best. It's which instrument will best suit your application? Many people recommend running the same sample on each instrument. This is a good idea, but it also tests the qualities of the people running the samples, not just the samples themselves.
What should never be forgotten is the after sales service. Which company has the best support in your area. Do they have experienced service engineers and applications support people? Talk to other users in the area if possible.
If you are linking it to an LC, and most people do, what kind of software support does the company provide? Most MS software will run most HPLCs, but the level of support for each HPLC with depend on it's origin. For example, I doubt AB would have great Waters HPLC Support and vice versa.
For the record, we have an AB 5600 and it's a great MS, for our application. I haven't used a G2-S, so I can't comment. I have had experience with their Q-TOF when they were Micromass and I loved them, great software too.
Good luck.
It's not just a case of which is best. It's which instrument will best suit your application? Many people recommend running the same sample on each instrument. This is a good idea, but it also tests the qualities of the people running the samples, not just the samples themselves.
What should never be forgotten is the after sales service. Which company has the best support in your area. Do they have experienced service engineers and applications support people? Talk to other users in the area if possible.
If you are linking it to an LC, and most people do, what kind of software support does the company provide? Most MS software will run most HPLCs, but the level of support for each HPLC with depend on it's origin. For example, I doubt AB would have great Waters HPLC Support and vice versa.
For the record, we have an AB 5600 and it's a great MS, for our application. I haven't used a G2-S, so I can't comment. I have had experience with their Q-TOF when they were Micromass and I loved them, great software too.
Good luck.
Our applications is mainly with small moleculars. I have been using a Waters entry level MS (single quad, I believe), I liked their software and hardware. But, some one told me, at high end, Waters is not as good as some other brand, such as AB, and plus the fact that no one is using a Waters QTOF around me, which makes me feel realy hesitated for the Waters model.
Actually, one of my friends actually strongly suggested me the Orbitrap, but my budget is not enough Obitrap, probably good for Exact plus without the quard modular. Is "Exact plus" great for small molecule study? And what LC is thermo using now for Exact plus?
I suggets the Q-Exactive (you can do excellent MS/MS) instead of an Exactive Plus.
We are running Agilent 1200er HPLC with our Q-Exactives, but you can also use Dionex Ultimate 3000.
Update:
Thank you for everyone's answers.
Budget is not acceptably by Waters for a Synapt G2. Instead of Obitrap Exact plus, Thermo is offering me their soon-coming new modeI QE focus. They told me the only change is down the resolution from 140,000 to 70,000, others are kept as same as QE. Now, I have narrowed the choices down to two models, Thermo Obitrap QE focus vs Waters Xevo G2-S QTOF. So, the point is still centered on whether choose Orbitrap or QTOF. Anyone with real experience on either Obitrap QE or Xevo G2-S QTOF, please, give me your suggestions, especially information for performance and stability, calibriation frequency, etc.
If you are not sure you can work with your choice of instruments with your specific application in their laboratory and decide based on your success achievement of quantitative and qualitative results of both instruments.
Sciex is more rugged instrument i have worked for more than 9 years those instruments and found more reliable compared to waters.
No idea about thermo instruments.
probably depends on your purpose, if more quantitation, then QTOF, or if more identification/qualitative purpose, then Orbitrap.
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