Dear all -

I'm trying to analyze hydrophobic patches on protein structures towards their size area. I have read previous postings and found some servers that would do such calculations. However, the best servers do not run at the moment and other solutions including molecular dynamic applications seem to be not easy. Maybe the dehydration dynamics could be informative but difficult to calculate.

The main aim is to distinguish wildtype and mutant proteins regarding their hydrophobic areas and to correlate those with experimental data e.g. the affinity to HIC columns etc. Finally it would be nice if based on this analysis the purification schemes of proteins could be optimized in silico.

Thanks for your help

Have a nice day

Kornelius