Please tell me about reliability according to instrumentation, expences and handling.
Dear Faheem,
Please use GC If your analytes are volatile , HPLC If your analytes are non volatile, but both are reliable and very good. the term reliability is method specific not instrument.
please specify your scope and sample for better answer
Regards
Selvan
Dear Faheem,
Please use GC If your analytes are volatile , HPLC If your analytes are non volatile, but both are reliable and very good. the term reliability is method specific not instrument.
please specify your scope and sample for better answer
Regards
Selvan
They are both reliable, depend on your analyte of interest if volatile GC is suitable, While HPLC most suitable for non volatile and semi volatile
Hi friends we can use HPLC for volatile also, but it is laborious and costly because we have to prepare mobile phase and the solvents which we use to prepare mobile phase are costly. If we see the GC no need to prepare the mobile phase and it is cost effective.
yes, i agree with Sivaleela. HPLC can also can be used for volatiles, but many of the volatile compound will not show good retention in HPLC, also GC is first come to the analytical field and then HPLC, GC is cost effective, universal for all the volatiles there fore people are saying so, at the same time non volatile also can be analyzed by GC by means of derivatization.
Regards
Selvan
it is true, if your chromatography is interfaced with mass spect. detector; GC MS will have very excellent Library (NIST, Wily)and can be used universally irrespective of mobile phase, stationary phase and other method parameters but LCMS is highly limited in library of mass spectra and may be method specific.
Regards
Selvan
it depends on application, in few cases GC is excellent but in more over cases HPLC is better. Method developement in GC is easier as compare to HPLC, but GC have some limitations.
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