Which of you tried to use corticoids for inducing diabetes ?

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Marcela Aldrovani

Hello, I suggest you try contacting Dr. Beatríz Martinez (from Brazil). She has experience with this model. E-mail: [email protected]

http://www.scielo.br/pdf/acb/v31n10/1678-2674-acb-31-10-00645.pdf

Abir Radjah

Ok ... many thanks for you Marcela !

S. M. Banan Khojasteh

Dear Abir, the routine way for induction of diabetes, is STZ injection. Why don't you try that method?

Entedhar Sarhat

Corticoids for inducing diabetes because they block the action of insulin which causes insulin resistance. , less glucose is able to move out of the bloodstream to be taken up by the muscles. This results in a high blood glucose level,and they cause the liver to start releasing extra glucose into the bloodstream.

You can benefit from the following links.

1. Guido Di Dalmazi, Uberto Pagotto, Renato Pasquali, and Valentina Vicennati, “Glucocorticoids and Type 2 Diabetes: From Physiology to Pathology,” Journal of Nutrition and Metabolism, vol. 2012, Article ID 525093, 9 pages, 2012. https://doi.org/10.1155/2012/525093.

2. Suh S, Park MK. Glucocorticoid-Induced Diabetes Mellitus: An Important but Overlooked Problem. Endocrinology and Metabolism. 2017;32(2):180-189. doi:10.3803/EnM.2017.32.2.180.

3. Hwang JL, Weiss RE. Steroid-induced diabetes: a clinical and molecular approach to understanding and treatment. Diabetes/metabolism research and reviews. 2014;30(2):96-102. doi:10.1002/dmrr.2486.

4. Antonio PerezSergio Jansen-ChaparroIgnasi SaigiIgnasi SaigiShow all 6 authorsRicardo Gómez-HuelgasRicardo Gómez-HuelgasGlucocorticoid-induced hyperglycemia, Journal of Diabetes 6(1),2014

5. Najla M Alduaiji* and Maha M Alduayji. Steroid Induced Diabetes; Obes Int J 2017, 2(4): 000165.

6. Suh S, Park MK. Glucocorticoid-Induced Diabetes Mellitus: An Important but Overlooked Problem. Endocrinology and Metabolism. 2017;32(2):180-189. doi:10.3803/EnM.2017.32.2.180.