Stent Can be coated with drug embedded in a surface polymer. Drug-eluting coronary stents can help prevent plaque buildup, promote good blood flow to your heart, and relieve chest pain. They may also lower your chances of having a heart attack.
Drug eluting stents are mainly coated with anti-proliferative, anti-thrombotic, anti-inflammatory drugs and re-endothelialization promoter. These drugs prevent stent related complications like restenosis and late stent thrombosis.
Most preferred drug in a drug eluting srent at present is Everolimus. Biolimus and Zotarolimus are also used. Sirolimus was the most preferred drug earlier but has now been replaced mosly by Everolimus. Paclitaxel was extensively used in the Taxus stent earlier but are currently not preferred.
Everolimus, Biolimus A9 and Zotarolimus , recentily Sirolimus are large used. Sirolimus was the first antiproliferative drug used on the first generation of DES (Cordis Cypher). Recently it has been widely reused on new generation stents being the most effective among the limus family and no longer having the exclusivity patent. SIrolimus is combined with polymers, often abluminal, with more homogeneous and short kinetics release that guarantee antiproliferative safety and efficacy. Sirolimus is also used on DRUG COATED BALLON and cardiac and PERIPHERALSTENT. Paclitaxel was extensively used in the Taxus stent but it is no longer used in the latest generation stents due to the lower therapeutic effect and the higher risk of thrombosis.
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