I'm currently working to prepare schiff bases derivatives of Tranexamic acid, as there is need to check the completion of reaction TLC is a technique for this purpose but tranexamic acid is inactive to UV because it lacks aromaticity in the ring , so I want to ask about the locating agent for tranexamic in order to compare it with my product.
There are several ways to derivatize a TLC. One of these which react with the majority of compounds is H2SO4 2N and heat. Since it is also present a nitrogen in the molecule the Dragendorff reagent may be useful.
To monitor the reaction process you may seed the reaction mixture on TLC together with the reactant/reagent (in different spots) and run the chromatography with a suitable solvent or mixture of solvents.
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