Which is the best solvent to extract natural coumarins from their natural sources? The extraction method I decided to employed is the microwave-aided technique.
Dear Abdelkader
I highly appreciate your answer and that of Prof. Frank T. Edelmann. Unfortunately, this grade of polymer is not available in my country because of the current circumstances. Please, can you advise me to apply another type of polymer or solvent mixture?
Depending on the source, if it is from plant, you could use aqueous ethanol, methanol or some other organic solvents
Dear Yasser Fakri Mustafa, since your decided to use a microwave-aided technique, I suggest that you check out the following article entitled "Study of polyethylene glycol as a green solvent in the microwave-assisted extraction of flavone and coumarin compounds from medicinal plants". The paper is available on ResearchGate.
Article Study of polyethylene glycol as a green solvent in the micro...
Hi Yasser,
You can use ethyl acetate, or methylene chloride. Good luck
Polar solvents including chloroform, ethanol, and a mixture of them.
Regards
Dear Yasser Fakri Mustafa, thanks again for the interesting question. Did you already try any of the suggested solvents or solvent mixtures?
Yes Sir. Water and aqueous ethanol were inappropriate extracting vehicles. Ethanol and methanol are a satisfying solvents but the isolation of natural coumarins via column chromatography is complicated by the presence of flavonoids. Therefore, I need an advice to resolve this issue
Dear Yasser Fakri Mustafa, thank you for the information. Attached please find a very useful review article which might help you finding the right solvents. Both coumarins and flavonoids are mentioned in this paper. Good luck!
Dear all, my contribution is an addition and an extension to Prof. Frank T. Edelmann's answer. Among polyethylene glycols I bring your attention to PEG-400, which has a genious effect on the kinetics and feasability of chemical reactions. My Regards
Dear Abdelkader
I highly appreciate your answer and that of Prof. Frank T. Edelmann. Unfortunately, this grade of polymer is not available in my country because of the current circumstances. Please, can you advise me to apply another type of polymer or solvent mixture?
Dear all, attached are files sheding light on the importance of PEG 400.
Dr. Mustafa, I don't think PEGs are under the restricted list of chemical forbidden to import. My Regards
Dear Abdelkader BOUAZIZ
PEGs are not found in the restricted list of forbidden chemical, this is a true comment. But, the comprehensive curfew and the difficulty in reaching the capital, Baghdad, resulted in the lack of this polymer in my college.
Regards
Dear Yasser Fakri Mustafa sorry to hear about these problems. As a possible alternative, please find attached an article describing the isolation of two coumarins from natural sources. In this case, the main solvent for extraction is methanol.
Dear all, additional hint is that extraction may be enhanced to a great deal if assisted by microwave or ultrasound. My Regards
Dear Abdelkader BOUAZIZ
Thank you for this information.
Regards
The best solvent to extract natural coumarins . If coumarin is in the form of glycoside then methanol or ethanol will be good solvents for extraction. If it is free the n-hexane or pet. ether can be used as solvents for extraction..
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