Hi, it depends on what effects you are looking to study. We extensively used B50 rat hippocampus cell line to investigate particle uptake, toxicity and potential for cell imaging. We found that this is easy to handle and robust cell line. This cell line is available from Sigma-Aldrich.
Please refer to the article "Magnetic nanoparticles in primary neural cell cultures are mainly taken up by microglia" by Josephine Pinkernelle et.al: Their conclusion is as follows:
"MNPs in primary cerebellar and in organotypic co-cultures were found to be predominantly taken up by microglia, suggesting a problem for in vivo application of these commercial MNPs because of the immune response. Future research needs to overcome this immune system activation with cell-specific targeting and additional functionalization."
hi.....very thanks to give me yours fruitful suggestion. Respected @ M.S Andrei Sapelkin and @ M.S KRIS Chellappa.....i already got yours article B50 Rat happocampal cell...