I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs works as a drug carrier which it is also known to be soluble in our blood.

If the drug is water insoluble, this means it cannot be dissolved in water. In this case, we need to melt the drug and mix it with lipid (heat them above 5 - 10 C of the lipid melting temperature) and then, mix them with the aqueous solution (surfactant + water). Hence, we will have an emulsion.

Was wondering, what is the state of the drug (eg: drug is solid at room temperature), if the melting point of the drug is higher (for instance 200 C) than the melting points of lipid (70 C) and surfactant used? Is it dissolve in the fluid or is it a dispersion?

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