The solubility of a drug is the most important data in its formulation. However, mathematical models are poor predictives, so I wonder which model you think is the best.
Unfortunately, none of the mathematical models exactly give you the solubility of your compound.
these articles may help you :
http://www.sciencedirect.com/science/article/pii/S0378517396048284
http://www.ncbi.nlm.nih.gov/pubmed/11259830
You may find the following paper interesting concerning the solubility prediction of drugs: http://pubs.acs.org/doi/abs/10.1021/ie3023675
This paper by Prof. Jouyban could help you if you are interested in cosolvent mixtures: http://www.ualberta.ca/~csps/JPPS10_3/MS_1168/MS_1168.html
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As above.
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