I am trying to search some literature on genes involved in degradation of classical naphthenic acids (NA). I have previously worked with CYP and ALK gene family but they are mostly studied for n-alkanes degradation, i.e. hydroxylases. Here, my question is that what is the scope of these genes being involved in the degradation of NAs. The substrate range for these genes is mostly up to C22, and they generally target straigh chain compounds; however, NA are often higher than C18 and are cyclic carboxylic acids. Can someone comment on it based on her/his experience? I would love to hear speculative answers/suggestions too. And if some knows that which genes are specifically involved in NA degradaton, or similar model compounds, I would appreciate to know that as well.

Thank you very much!

Arslan