TB is treated with a combination of four effective antibiotics. Depending on the sensitivity of the tuberculosis mycobacteria, there are treatment options for drug-susceptible TB. This includes the well-known isoniazid, rifapentine, ethambutol, and pyrazinamide, usually prescribed for 2 months, followed by a 4-month period where the number of medications is reduced, keeping only rifampicin and isoniazid.
In cases where the mycobacteria of TB become resistant to medications, there are several treatment options. The main idea is to keep four effective medications (meaning the ones that TB bacteria do not have resistance to).
Below are the abbreviations of anti-TB drugs:
Am: Amikacin
Amx/Clv: Amoxicillin/Clavulanate
Bdq: Bedaquiline
Cfz: Clofazimine
Cs: Cycloserine
Dlm: Delamanid
Ipm/Cln: Imipenem/Cilastatin
Lfx: Levofloxacin
Lzd: Linezolid
Mfx: Moxifloxacin
Pa: Pretomanid
Pto: Prothionamide
The main regimens accepted in Tajikistan from all WHO-recommended options are listed below (the number before the names of drugs is the standard duration of treatment):
BPaL: 6Bdq-Pa-Lzd (sometimes Mfx or Cfz can be added)
9Bdq-Lfx-Lzd-Cfz-Cs
9Bdq-Lfx-Lzd-Cfz-Dlm
9Lfx-Lzd-Cfz-Dlm
Individual regimen: Can be prescribed if there are any large residual changes, bone TB, or an allergic reaction to drugs. In an individual regimen, the combination of drugs can be different. The difference is that it is prescribed for more than 12 months, with the standard duration of the course of treatment being 15 to 18 months in such cases.