Many drugs have a degree of nephrotoxicity. Which are the main ones and which generate more tubular or glomerular lesions?
Hi,
In the case of tubular toxicity "inhibition of apical efflux transporters diminishes drug exit from renal tubular cells, which can lead to increased drug accumulation and nephrotoxicity." that means drugs with high affinity for active transporter systems could have higher toxic potential than drugs with lower affinity. By dividing drugs into those that have a high affinity for active transport systems or are not, it is possible to distinguish potentially toxic from those whose toxicity is lower due to tissue accumulation.
Article Renal drug transporters and their significance in drug–drug ...
Drug-induced glomerulopathies may be associated with:
Article Drug-Induced Glomerular Disease: Attention Required!
Both papers show some nice examples and more useful details ....
Examples of nephropathies and drugs examples see:
https://www.ncbi.nlm.nih.gov/books/NBK553144/?report=printable
Best regards
Tomasz
Many drugs are nephrotoxic and their nephrotoxicity can also vary based on the health of other organs such as liver. An important clinically relevant question would be that which are most commonly used drugs that are nephrotoxic and in my opinion, NSAIDs are the most commonly used drugs contributing to nephrotoxicity.
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