is there any metodolty from the WHO or CDC for evaluate the IC50 of certain compounds against T. cruzi or Plasmodium spp.?
if so, where can i find the articles?
There are many kits for plasmodium species. You can get them in the market.
You can calculate that parameter by non linear regression or find some help at https://www.ncbi.nlm.nih.gov/pubmed/?term=Experimental+models+in+Chagas+disease%3A+a+review+of+the+methodologies+applied+for+screening+compounds+against+Trypanosoma+cruzi or at Article In vitro and in vivo experimental models for drug screening ...
https://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/BloodDonorScreening/InfectiousDisease/UCM281126.pdf
Hello my dear Victor Mario
I have studies in this field, the methodology and results are presented in the following articles.
I have studies in this field, the methodology and results are presented in the following articles.
The half maximum inhibitory concentration (IC50) measures the power of a substance in a specific biological or biochemical function. IC50 can be calculated by this formula: Y = a * X + b. I have given the link below which can be helpful for you.
http://www.sciencegateway.org/protocols/cellbio/drug/hcic50.htm
- Badges
- Science topic
- Similar topics
- Microbiology
- Assays