The qRT-PCR was performed to investigate the expression of serum NRAGE in 107 patients with HCC, 98 benign liver disease patients, and 89 healthy controls. As shown in Figure 1, the average value of NRAGE expression was 0.917±0.295 (mean± standard deviation) in patients with HCC, 0.569±0.207 in benign liver disease patients, and 0.362±0.182 in healthy controls. Serum NRAGE was significantly increased in patients with HCC compared with the controls (all, P