Currently usual doses of antifungal drugs are ineffective in most of the fungal infections. We prescribe usually double/triple drugs in higher doses for fungal infections to cure it.
In tuberculosis, there are MDR and XDR tuberculosis. When tuberculosis is resistant to at least two of the most powerful first-line anti-TB drugs isoniazid and rifampin, it is multidrug-resistant tuberculosis (MDR-TB). When tuberculosis is resistant to isoniazid and rifampin plus any fluoroquinolone and at least one of three injectable second-line drugs (i.e., amikacin, kanamycin, or capreomycin), it is extensively drug-resistant TB (XDR TB).
Like that of drug resistance tuberculosis, when should we label fungal infections as drug resistant infections?
When fungal infections no longer respond to antifungal drug treatment. Fungi are sensitive to specific antifungal drugs. This can be identified by antifungal susceptibility tests after culture done with the appropriate patient's samples.
Fungal infection can be labeled drug resistant when a known fungicide/fungicides are unable to kill the fungi when administered at doses equal to or higher than the usually recommended dose but within the tolerance limit of the patient.
It depends on the organism and the antimycotic. Is this a theoretical question or are you looking for sources of information on limits
Fungi, like bacteria, can develop antibiotic resistance, when germs like bacteria and fungi develop the ability to defeat the drugs designed to kill them. Fungi are more closely related genetically to humans than they are to bacteria. Therefore, it is hard to develop antibiotics that attack fungi without damaging human cells. Antifungal resistance occurs when fungi no longer respond to antifungal drugs.
https://www.cdc.gov/fungal/antifungal-resistance.html
https://theconversation.com/why-the-cdc-warns-antibiotic-resistant-fungal-infections-are-an-urgent-health-threat-127095
Also, kindly check:
https://www.frontiersin.org/research-topics/14111/worldwide-emergence-of-drug-resistant-fungi-from-basic-to-clinic
https://ejhp.bmj.com/content/29/2/109
Dear Harasit Kumar Paul . Antifungal resistance occurs when fungi no longer respond to antifungal drugs.
See the following useful link: https://www.cdc.gov/fungal/antifungal-resistance.html
Also, occurs when an antifungal medication no longer works to treat a fungal infection. See the link: https://my.clevelandclinic.org/health/articles/21557-antifungal-resistance
Kindly see also the following useful link: https://www.healthline.com/health-news/everything-you-need-to-know-about-the-new-deadly-drug-resistant-fungus
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