Thanks for invitation, I have no idea, it is not my specialty.
Regards, Emad
@Manar, thanks for the wonderful question but i really do not have an idea but i am interested in knowing more
Please check it
http://www.elsevier.es/es-revista-endocrinologia-nutricion-12-articulo-genes-obesidad-una-relacion-causa-consecuencia-S1575092211002427#tbl0005
As obesity is polygenic disease, there is no ONE -the most important gene. There are lot of genes changed in obesity and probably nobody still knows which of them are really important :)
There are no single gene related to obesity, it is a polygenic disease, influenced by the environment in which will there for example abundance of food and also the stress level that keeps us from eating.
Some abnormal forms of fat deposition like partial lipodystrophy maybe related to single gene
Hi,
Obesity is the result of an interplay between environmental and genetic factors. Studies have identified variants in several genes that may contribute to weight gain and body fat distribution; although, only in a few cases are genes the primary cause of obesity.
Refer the following:
1. Albuquerque D, Stice E, et al.. Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective. Mol. Genet. Genomics 2015;290:1191–221. PMID: 25749980 doi:10.1007/s00438-015-1015-9.
2. Albuquerque, David, Nóbrega, Clévio; Manco, Licínio; Padez, Cristina. The contribution of genetics and environment to obesity. British Medical Bulletin 2017; 1–15. doi:10.1093/bmb/ldx022.
3. Kushner, Robert (2007). Treatment of the Obese Patient (Contemporary Endocrinology). Totowa, NJ: Humana Press; 2009 p. 158. ISBN 1-59745-400-1.
4. Adams JP, Murphy PG (July 2000). Obesity in anaesthesia and intensive care. Br J Anaesth 2000;85(1):91–08. PMID: 10927998. doi:10.1093/bja/85.1.91
Sirtuin 1 is now an important gene related to obesity. Its inactivation leads to adipose tissue-crosstalk defects with the development of NAFLD and obesity. Caffeine is a modulator of Sirt 1 and with Sirt 1 activators and inhibitors that may be important to the prevention of stroke and the induction of obesity that now involves the gene Sirtuin 1. ONLINE REFERENCES: 1. Avasimibe and Sirt 1 Activators Reverse NAFLD and Obesity. Nov Appro Drug Des Dev. 2017; 1(3) : 555561. 2. Defective Inter¬play between Adipose Tissue and Immune System Induces Non Alcoholic Fatty Liver Disease. Updates Nutr Disorders Ther. 2017; 1: 3.1 3. Caffeine Consumption and Induction of Obesity in the Developed World. Ann Obes Disord. 2017; 2(1): 1018. 4. Nutrition Therapy Regulates Caffeine Metabolism with Relevance to NAFLD and Induction of Type 3 Diabetes. J Diabetes Metab Disord. 2017; 4: 019. 5. Martins IJ. Drug Therapy for Obesity with Anti-Aging Genes Modification. Ann Obes Disord. 2016; 1(1): 1001. 6. Unhealthy Nutrigenomic Diets Accelerate NAFLD and Adiposity in Global communities. Journal of molecular and genetic medicine: an international journal of biomedical research 03/2015; 9(1). 7. (2014) The Global Obesity Epidemic is Related to Stroke, Dementia and Alzheimer’s disease. JSM Alzheimer’s Dis Related Demen¬tia 1(2): 1010. 8. (2014) Induction of NAFLD with Increased Risk of Obesity and Chronic Diseases in Developed Countries. Open Journal of Endocrine and Metabolic Diseases, 4, 90-110 9. (2013) Increased Risk for Obesity and Diabetes with Neurodegeneration in Developing Countries. J Molecular Genetic Medicine S1: 001
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