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Dear colleagues Dr. Allawi,

Thanks to a very curious question you asked, if I'm good understood !?

My answer to it is as follows:

If I could give an answer just adopt the name and from its many years of experience as nefro-immunologist in the treatment of autoimmune diseases, which include lupus and one of its most common effects at this point (60-70%) in the kidney-Lupus nephritis!

As every autoimmune disease treated by the latest therapeutic approaches combination therapy for various groups of drugs, which I used in daily practice in the treatment of these patients:

-Calcineurin Inhibitors (Cyclosporine)

-Non Specific Inhibitors of Cell division / Nucleotide Metabolism - inhibitors biosintese nucleotides ((azathioprine, cyclophosphamide, methotrexate, chlorambucil)

-Lymphocyte Selective Inhibitors of Cell Division / NucleotideMetabolism

- (Mycophenolate mofetil)

- Agents Affecting AntigenPresantation

- Cortikosteoids (Methylprednisolone- Prednisone)

I remain symptomatic therapies nonsteroid antirheumatic drugs, analgesics, anti-malaria drugs, antipyretics, etc.

I am sending you my two links as references from my  two books where those detailed etiology, diagnosis of the clinical features and treatment of autoimmune diseases, of course including SLE-- Lupus nephritis !

And of course the other references of other authors that I used as my "base record" in the treatment of these patients!

Unfortunately, due to objective reasons (the period of the war and after war period, I  have to left my hospital,  in my country, I can not give you statistical evidence only give my personal expiriens! I  hope so You can this use in every day praxis!

Nice Greetings from Sarajevo winter

Jasenko Karamehic

Dear colleagues dr.Allawi,

Also, and this my book entitled "Clinical Immunology"

issued in 2007 years!

author Jasenko Karamehic, Zehra Dizdarevic and Associates

and section 8 below

: Under the title

"Autoimmune disease" - Chapter 8, 

entitled "Systemic lupus erythematosus" on pages Chapter 9, pages s: 187-192

The book is supplied in electronic form in my bibliography-CV on my side on Reaserch Gate.

Best Wishes

Jasenko Karamehic

Dear colleagues Dr. Allawi,

Also, and this my book entitled

- "The use of drugs and nephrology, dialysis and kidney transplantation," issued in 2002 years!

-author Jasenko Karamehic

You have the in this book describes a large number of drugs (250) arranged in alphabetical order of their pharmacokinetics and pharmacodynamics that sye used in kidney transplantation and in the treatment of autoimmune diseases, of course including SLE - Lupus nephritis, immunosuppressive therapy protocols or kidney. I think a lot can aid in education as well as teams of doctors who sye prepare for a kidney transplantand on deparment for autoimmune diseases, among them (SLE)!

The book is supplied in electronic form in my bibliography CV on my side on Reaserch Gate.

Best Wishes

Long-term study of mycophenolate mofetil as continuous induction and maintenance treatment for diffuse proliferative lupus nephritis

TM Chan, KC Tse, CSO Tang, MY Mok… - Journal of the …, 2005 - Am Soc Nephrol

... serum albumin

Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis

DT Boumpas, HA Austin, JE Balow, EM Vaughan… - The Lancet, 1992 - Elsevier

... of pulse therapy have been published elsewhere.21 All patients were treated with prednisone,

starting at 0-5 ... Our choice of 6 months of treatment was arbitrary; at the time this study began, three ...

only a short burst of pulse methylprednisolone for a few days at the start of therapy ..

[PDF] intramed.net

Long-term outcome of patients with diffuse proliferative lupus nephritis treated with prednisolone and oral cyclophosphamide followed by azathioprine

TM Chan, KC Tse, CSO Tang, KN Lai, FK Li - Lupus, 2005 - journals.sagepub.com

... pertain to the starting dose of corticosteroid and its rate of reduction, and the choice, duration ...

between serial renal function and the renal reserve at baseline and at one year after treatment. ...

This prospective cohort study included patients under the care of the SLE clinic of the ...

Treatment of membranous lupus nephritis with nephrotic syndrome by sequential immunosuppression

TM Chan, FK Li, WK Hao, KW Chan, SL Lui, S Tang… - Lupus, 1999 - journals.sagepub.com

... context, vascular complications account for more than 20% of late mortality in patients with SLE,

and represent ... that improvement in proteinuria may not be obser- vable for up to 6 months after

starting treatment. ... Treatment of nephrotic membranous lupus nephritis TM Chan et al ...

[HTML][HTML] Azathioprine/methylprednisolone versus cyclophosphamide in proliferative lupus nephritis. A randomized controlled trial

…, Dutch Working Party on Systemic Lupus … - Kidney international, 2006 - Elsevier

... CY, group treated with intravenous cyclophosphamide and oral prednisone; AZA, group treated

with ivMP, azathioprine, and oral prednisone ... Both the SLE Disease Activity Index 17 and the

physician's visual analog scale (VAS) did not differ between the treatment groups ...

… cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis

CS Yee, C Gordon, C Dostal, P Petera… - Annals of the …, 2004 - ard.bmj.com

... in the continuous group occurred in a patient who had been withdrawn before starting the study ...

group was malignancy, while the other died late (3.3 years after the start of treatment ... adopted

as the mode of choice for cyclophosphamide administration in the treatment of lupus ...

Dear Dr.Allawi,

I forgot to put the link of another of his books that recently came out!

Although the title says it is used in organ transplantation, it is clear to you as I believes that the immunosuppressive drugs equally be used in clinical immunology, autoimmune diseases including most in the treatment of SLE and its most frequent complications of lupus nephritis present (60-70%)!

The book came out 2012 years under the title

"Immunosuppressive therapy and its use in organ transplants"

author:

Jasenko Karamehic, Sebija Izetbegovic and associates.

It is located in an electronic form on my site at ResearhGate to list my books!

Regards from Winter and cold  Sarajevo

Dear Jasenko

Thanks alot for kind attention and interest

Your data is highly valuable 

Dear Ali Abdulmajid,

thank a lot !

Best Wishes

Jasenko

I'll gladly follow your scientific work and project and we remain in the academic and communication!

regards

Jasenko