Countless number of papers have discussed the importance of NO with certain low levels and how they modulate the cell proliferation as well as the migration of tumor cells. Other papers have discussed the importance of the high levels for inducing the cell apoptosis as well as the cytotoxicity towards the protection against malignancy.
What will happen if NO is completely absent from the tissue?
Depends on the tissue. Could you be more specific? Moreover, NO is extremely labile and very difficult to quantify in in vivo specimens. Did you measure NO2- and NO3-)
The question is initially for discussions and to find if there any contributions regarding that issue.
Let's consider the breast cancer tissue. There are controversial results regarding the importance of NO in this tissue, where some reports found out the high levels may be beneficial for killing the tumor cells, whereas others reported the importance of the low levels in that process.
Yes, the common method is the Greiss reagent method.
Dr. Harald
Yes, and that is idea of designing NO-releasing molecules for cancer treatment.
But what would happen if the cells became completely deprived of the NO. In that case, neither the signalling nor the radical effects will be existent. Right?
The situation with a complete absence of NO seems somewhat unrealistic given the fact that there is always a pool of nitrites / nitrates in the body (coming from water, air, and food), a number of cells can release NO due to the functioning of a number of enzymes (such as NO synthase, xanthine oxidoreductase and etc.). It seems to me more interesting to discuss how far we can go with adjusting the level of NO in the tissue without risking adverse health effects.
Dr. Victor
I agree with you regarding the continuous existence of NO in the tissue, but what will happen in the case of limiting the NO to its minimum amount in the tumor tissue?
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