Hi everyone! I would like to analyze my results and see if there is a statistical significance. When we compare 2 groups of 80 patients each and let's assume that we have wild type, heterozygotes or homozygotes for the mutant allele, should we use chi-square test or Fisher's test? Can I use the Bonferonni correction?
Jochen Wilhelm
If you want to see if the distributions of genotypes are different in your two groups: chi-squared test. In this case I don't see why you should need a correction for multiple testing.
It may also be interesting to see if the distributions significantly deviate from the Hardy-Weinberg equilibrium.
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Maria Levkova
Jochen Wilhelm Thank you for your answer! That is a good piece of advice!
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