Good day scholars.
Because of the toxicity associated with BPA, there is a shift to various analogues of BPAs. However, these analogues have also been reported to be toxicants. And humans are not exposed to just one of them. Rather than using a single analogue to induce toxicity, I intend using a mixture of about 2 or 3 of them.
In mixing the toxicants, ratio 1:1:1 might not be the best since they have different LD50. Is there any guiding principle or advice on deciding the quantity of each of the toxicants that could be used in the mixture?
Thanks.
Olayinka Sunday Okoh We did a lot of ecotoxicological works with monotoxicant and youre right, in the real world, there will be a multitude of toxicants and working with two toxicants simultaneously will be a good start.
see
Chapter Mixture Effects in Ecotoxicology
This is a very good and real idea. It is possible to combine several toxins in the environment and this can be a good start.
The following article can be helpful:
"Mixture toxicity of three toxicants with similar and dissimilar modes of action to Daphnia magna"
Article Mixture Toxicity of Three Toxicants with Similar and Dissimi...
Good luck
It is pertinent to determine the mechanism/mode of action of each of the analogues or toxicants you intend to use.
More so, the type of toxicity you want to induce will help your choice of toxicants. Some toxicants may be more potent for either acute, sub-acute, developmental or chronic toxicities etc
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