plasma treatment most common. We have tried F127, which works well. Hydrogel precursors such as fibrin, collagen is also helpful.

Zijie Meng, that's why I mentioned else than plasma treatment, Could you please recommend the articles in which they have used fibrin and collagen.

Also check out our publication on this topic. To improve wettability of PDMS-based devices, we used alginate, a naturally derived polysaccharide, and covalently bound to the PDMS surface.

Surface modification of Polydimethylsiloxane by hydrogels for microfluidic applications

Article Surface modification of Polydimethylsiloxane by hydrogels fo...

DOI: 10.1515/cdbme-2019-0024

Kerstin Frey thanks, we are using PMMA chip.

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hey

the only method I could find is coating-based methods. you can use poly ethylene glycol or poly vinyl alcohol or even surfactant material.