Variables that are to be handled primarily (as per my understanding) are Solar Radiation and its corresponding shadow due to buildings and trees of adjacent area, Wind profile disturbance due to buildings of adjacent area, etc., In addition to this, Turbulence, moisture etc., will also come into picture.
Also the Lateral Boundary Condition that one has to use also plays a key role which may need info on the whether the area is homogeneous or has lot of variability.
I would like to discuss upon the numerical schemes that one can use to merge the simulation results to give combined area simulation results.