I am conducting an exercise program for people with alcohol problems. Many alcohol misusers take medication such as methadone, baclofene. They can be on antidepressants or sedatives. Does this medication have an effect on their response to exercise?
In case of depressive disorder arise from alcoholic problem may leads to decrease in the synthesis of new neurons in the adult hippo-campus so medications as anti depressive drugs may help increased the synthesis of new neurons in the brain, and it was noted that the therapeutic effects of antidepressants occurred over a time span that approximates the time taken for the new neurons to become functional. Like antidepressants, exercise also increases the synthesis of new neurons in the adult brain, so exercise alone may alleviate the symptoms alcoholic depressive disorder without using anti depressive drugs but if anti depressive drug taken during exercises , it move in same positive healthy way for depressed alcoholic patient.
Baclofen is medication that relaxes skeletal muscles, baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter in the brain. It is believed that baclofen, acting like GABA, blocks the activity of nerves within the part of the brain that controls the contraction and relaxation of skeletal muscle.Baclofen used in muscle spasms, multiple sclerosis. Commonly reported side effects of Baclofen include weakness, fatigue, multiple sclerosis, multiple sclerosis aggravated, fall.In certain study, decreasing of exercise tolerance following baclofen intake (latest reports from 8,954 patients) has been reported by people with high blood cholesterol, high blood pressure, asthma, chronic obstructive pulmonary disease, multiple sclerosis.
Generally all of these medications you mentioned will have a negative effect on response to exercise. Assuming patients with alcohol use disorder, they really should not be prescribed sedatives (benzodiazepines or muscle relaxants) or opioids (methadone) except when absolutely necessary, as they both substantially depress RESPIRATORY RESPONSE and generally make respiration more difficult. In combination with alcohol, opioids and benzodiazepines can contribute to MORTALITY through respiratory depression. On the positive side, regular exercise enhances respiratory response and should reduce mortality (or substantial morbidity) from mixing these three addictive substance types. Simply put, a substance-use-disorder patient who is exercising regularly has a better chance of survival, but these substances are a deadly combination that also make exercise more difficult.
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