I am conducting a PhD study on drug repurposing for Alzheimer's disease, focusing on preclinical evaluations including in vitro, in vivo, behavioural, biochemical, and histological analyses. I am seeking suggestions for test compounds—such as market-available drugs, metabolites, or other chemicals—that could be suitable for this research. Any insights or recommendations would be greatly appreciated. Thank you in advance for your help!
Beta amyloid and tau proteins have been elaborated with the disease, but exact cause of dementia not been pinpointed. Assay of neurotransmitters both stimulatoty and inhibitory may be assayed. Also, free radicals in serum including superoxide, hydroxyl radical and nitric oxide might be assayed. Also serum electrophoresis for abnormal proteins may be done. This researcher has put forward serum glutamine synthetase as tuberculosis diagnostics by transfer reaction. This researcher had estimated serum glutamine synthetase by transfer reaction for Alzheimer's disease and it was undetectable. I suggest for radio immunoassay or elisa technique to go for it to measure in a very very low concentration if it is present.
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