We are looking for cell surface molecules or receptors in active fibroblasts or myofibroblasts in CKD patients to investigate renal fibrosis mechanism.
What molecules or receptors are highly specific and more rich in these cells?
Type IV collagen 7S is the specific marker of the organ fibrosis. Type IV collagen 7S is known to be significantly elevated in diabetic patients with micro-or macroalbuminuria as compared with those with normoalbuminuria and healthy controls(Nephron 1996;73:601–605 ). It has also been reported the profound elevation of the type IV collagen 7s domain in NASH patients with advanced fibrosis (J Gastroenterol. 2007 May;42(5):375-81.).
Sorry, I made a misunderstanding on your question. Surely, type IV collagen 7s is the novel marker for liquid biopsy of renal fibrosis underlying CKD development. However, the most promising candidate molecule expressed in fibroblasts is alpha-SMA. This is also recognized as the myofibroblast marker. Given that fibronectin is also highly expressed in those cells, they have acquired the more mesenchymal characteristics.
http://www.bing.com/images/search?q=alpha-SMA+fibroblast+kidney&view=detailv2&&id=2BFB20B1EE669CF5207115417C11021A31898683&selectedIndex=2&ccid=p%2bfHoktz&simid=608011320968478967&thid=OIP.Ma7e7c7a24b73669b4f820e235a98907ao0&ajaxhist=0
Thank you very much, Dr. Yoshida.
But these markers are likely to be located in cytoplasm. I would like to know any cell surface marker.
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