What kinds of macropinocytosis/phagocytosis is inhibited by Cytochalasin D?

06 June 2015 1 433 Report

Cytochalasin D has been used as inhibitor of macropinocytosis/phagocytosis. I am wondering what kinds of macropinocytosis/phagocytosis could be involved in when using Cytochalasin D as the inhibitor? Would receptor (scavenger receptor, mannose receptor or TLR etc.)-mediated phagocytosis be inhibited?

Navin Gopaldass

Macropinosis and Phagocytosis are endocytic events that require actin polymerisation. As Cytochalasin D is a potent inhibitor of actin polymerisation, it is a general inhibitor of macropinocytosis and phagoyctosis.

Check out this review for the role of actin in endocytosis and membrane traffic:

http://www.ncbi.nlm.nih.gov/pubmed/17139330

Hope this helps.

Cheers,

Navin

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