Please share your personal vision of developments in glioblastoma therapy within the next decade. Do you feel that meaningful refinements of surgical technique, operating room technology and radiation therapy are still possible? Will immunotherapy, targeted therapy, drug cocktails or modifications of the blood-brain barrier play a more important role? Or will we still be using temozolomide as the mainstay of treatment? Thank you very much for your opinions.
"Prognosen sind immer unsicher, besonders wenn sie die Zukunft betreffen"
I hope that in ten years from now, we will have more therapies for GBM than now. I guess that we will use combinations of individualized drug cocktails + immunotherapy, tailored to the individual tumor. I think that surgery will change, perhaps in the way that breast cancer surgery has changed, that liquid biopsies will become a routine measure and I hope that TMZ will not be the only drug that has shown a survival advantage in patients with GBM. Also the trial structure must change - Will all this be achieved within ten years? I hope so...
I believe that the future is in imaging modalities. Basic research will prove that only the image-guided biopsies and differential diagnosis and treatment assessment will help patient's quality of life.Think of all the wrong histopathological results. I personally don't believe in miracles regarding therapy. However, biomarkers are a hope for protection. MRI will be a routine, irrelevant to illness, optional examination to prevent late diagnosis. I also believe that we will finally understand our misleading therapeutical approach, such is ant-angiogenic. The timing of treament matters, not the type of it.
Research! GB has an explanation and warnings. We have to focus on the mechanisms, not the drugs. GB is not resistant, is adaptive.
-Marilena-
I've been in this business for 40 years. Yes, it's been depressing at the slow pace of progress. There is now more hope than ever.
Ten years should see this field much more focused & progressive in pt management giving the client informed choices rather than one size fits all. Always there is hope & that should never be taken from the patient/ caregivers. SL
very few progress with ablation surgery, radiotherapy and quimio, with knew knowledge the molecular targets, inmunotherapy expect hepl survivalof fatal end
In next ten years molecular characteristic will be more clearly defined.Surgical resection will be improved with newer imaging technique and use of ALA etc.
There will be a shift towards employing PD1 or PDL1 inhibitors or even check point inhibitors as well.
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