What is the upper limit of DMSO infusion (concentration at 0.5µl/h for 7 days) in BALB/c mice (20g) without interfering in inflammation?

04 March 2013 1 7K Report

A DMSO-solved anti-inflammatory drug shoud be infused via osmotic pump.

We had some serious problems in experiments with DMSO and liver inflammation. Unfortunately, DMSO can prevent injury and inflammation at doses ranging around 1 microliter per animal / day in our hands. In fact, we were quite amazed about how antiinflammatory DMSO was in our model.

Maybe you could try ethanol, it was the best substitute we found.

Good luck!

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