If a researcher purchases the same chemical from different vendors, there can be variation in solubility. The following factors can affect the solubility of the same chemical: solvent of crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature, dissolved oxygen present in the solvent, and grade of solvent. They mostly provided the solubility information for differnt solution such as PBS pH 7.8, pH 7.2, and HPLC-grade solvents (DMSO, ethanol, methano, DMF). However, the exact aqueous solubility of sulforaphane was not provided. What will be its stability in water? Can someone update regarding it?
Dear Laxman Subedi I guess it is because Sulforaphane is, based on its chemical structure, a hydrophobic substance. Therefor good solubility can only be expected in solvents like DMSO, ethyl acetate and possibly ethanol. See for a good paper on this:
Article Optimization of an Extraction Process to Obtain a Food-Grade...
https://www.mdpi.com/1420-3049/26/13/4042Best regards.
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