For rat and mouse,
The LD50 for METH with intraperitoneal (ip) administration is 55 and 57 mg/kg, in rat and mouse, respectively (Davis et al., 1987; Yamamoto, 1963). But temperature is very important eg. at 29oC 80% of rats were died with 9 mg/kg i.p. administration just 4-5 degree above ambient temp.
For human,
A lethal dose of methamphetamine varies depending on characteristics of the drug and the user. In fact, each person has a different sensitivity to a specific amount of methamphetamine due to personal tolerance to meth. Therefore, toxic levels are different for each individual. Meth overdose may also be complicated by other drugs the user may have taken. Diseases that the person may have developed also play a role due to the current health condition of the body.
Oral administration = ~ 150mg a day
Injection (iv)= ~100mg or higher
Smoking and snorting methamphetamine = ~50 mg or higher
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