Most papers about normal mode analysis are claiming that low frequency normal modes correspond to protein conformation changes. In most cases software visualizes those modes as arrows. However, NMA is about oscillation analysis, not translation. So, is there any rationale, that low frequency mode may be interpreted as conformational change, that is a transnational movement? Or are we just assuming, that conformational changes, eg. upon ligand binding, are just very low frequency oscillations?

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