What is the support for the notion that death ensues as the total tumor burden reaches 1 kg?

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Ravi Pottathil

Dear Christer

It depends on the site of tumor, doubling time. The correlation of 1Kg tumor mass with lethality was originally derived from therapeutic unresponsiveness.

Journal of Surgical Oncology 1997;65:284–297

http://www.bioquest.org/summer2010/wp-content/blogs.dir/files/2010/02/Friberg1998.pdf

Attached

Carlos Sonnenschein

Good question!

Robert Kiss

What do you include in the term "tumor".

Tumor includes benign as well as malignant diseases.

Whatever the size / weight, a bening tumor of several kg can be cured by surgery.

A malignant tumor is a cancer.

A glioma will never reach 1 kg ... same story for lung cancers ...

Patients with metastatic melanoma can die with total melanoma (cancer) added masses of >> 1 kg.

A famous US movie star died some decades ago from a gastric cancer > 1 kg ...

An so on ...

So, everything depend on the organ origin in which a cancer originates.

Best regards

Robert

Dear Colleagues,

I retrieved this book chapter that could bring some responses to Christer's question.

All the best