From our previous research " ‘Peroxidase’ mimicking Nano-assembly Mitigates Lipopolysaccharide-Induced Endotoxemia and Cognitive Damage in the Brain by Impeding Inflammatory Signaling In Macrophages "
We observed that LPS administration via i.p injection has damaged vital organs like lung, liver and kidney.
Does LPS activate tissue resident macrophages and cause the tissue damage or is it the inflammatory cytokines causing this damage?
It's both.
Tissue resident macrophages (if they don't travel... and this is a big IF) once activated will call in other monocytes and other cells to the site. And these called in cells... don't actually just stay at the site of inflammation... they will travel. And inflammatory cytokines even though produced at the tissue site, will still go into circulation. And LPS.. even though injected IP.. can still enter the blood stream and activate cells in circulation.
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