Does someone have any evidence about proMBP changes in preeclamptic women?
Yes it is potentially involved in the development of preeclampsia and in pregnancy-induced hypertension.
Please, see this link
http://www.ncbi.nlm.nih.gov/pubmed/21270431
ProMBP inhibits Ang-1 generation from angiotensinogen and thereby potentially influences the regulation of blood pressure.
The angiotensinogen/proMBP complex is the main constituent of high molecular weight in normotensive individuals. Increased levels of high molecular weight angiotensinogen have been observed in preeclampsia.
Eleveted levels of proMBP is associated in the development of pregnancy induced hypertension,preeclampsia.
The proMBP is a novel first trimester serum marker for adverse pregnancy outcome. The median was significantly reduced in pregnancies with preeclampsia and gestational hypertension. The best screening performance was found for preeclampsia including the covariates proMBP and nulliparity yielding an area under the curve equal to 0.737 (p < 0.0005) and a 75% detection rate for a 30% false positive rate.
Thanks. Could Dr Eduardo Reyna-Villasmil please provide me with the reference included in your comment?
We are carrying out a study on the matter.
Kind regards,
FRPL
Here is the infor you request
Pihl K, Larsen T, Rasmussen S, Krebs L, Christiansen M. The proform of eosinophil major basic protein: a new maternal serum marker for adverse pregnancy outcome. Prenat Diagn. 2009 Nov;29(11):1013-9. doi: 10.1002/pd.2331.
http://onlinelibrary.wiley.com/doi/10.1002/pd.2331/pdf
I hope it could be useful for your research
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