Dear Scientists,
I would like to ask you for sharing your experience regarding the relationship between molecular weight and size (nm). I know that there is no accurate way to find that relationship. However, I would like to get a rough idea. For example, what is the size (nm) of a dialysis membrane with cutoff of 100 kDa.
Many thanks in advance
Dear S.M.Ali Dadfar, it is not specified the type of molecule in question. If it is a polymer, there are two concepts to scale the dimensions of macromolecules, which are chain end-to-end distance and radius of gyration. My Regards
In general, the size is likely to be bigger if the MW is large. But there is no direct correlation between both of them.
The pores are not one specific diameter. There is a distribution at any given molecular weight cutoff. Moreover, the shape of a protein influences it ability to pass through the pores, in addition to the mass of the protein. Nevertheless, this reference should be useful as a rough guide.
https://www.interchim.fr/ft/D/Dialya.pdf
The synthetic macromolecules and proteins need not follow the same trend. As Dr.Shapiro indicated that there is a distribution of molecular weight and that is the reason why the MW of these systems are only average(Mw and Mn).
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