Generally, in advanced ovarian cancer inhibition of autophagy is beneficial. Went through few articles which have suggested that cellular senescence could be used as a therapy for ovarian cancer. But according to the current literature, the inhibition of autophagy prevents cellular senescence. Can anyone tell me What is the relationship between Cellular senescence and autophagy in ovarian cancer?
Estrogens (E2) are concerned with the etiology of ovarian cancer. Estrogens make production and anti-estrogens slow down ovarian cancer growth in vitro and in vivo. Estrogens increased the generation of reactive oxygen species (ROS), Autophagy blocked ROS inhibition. Kindly find the attached article.
Hello Luxitaa
There is a close association between autophagy and cellular senescence by means of their collateral regulation via common signaling pathways.
Inhibition of autophagy does not entirely abrogate the senescence response. Both these processes tend to occur in parallel.
Please refer to the research article below for more information about the relationship between autophagy and cellular senescence in cancer.
J Pharmacol Exp Ther. 2012 Dec, 343(3):763-778
doi: 10.1124/jpet.112.197590
Best Wishes.
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