What is the reason patients have to fast for bone marker testing, i.e. CTX?

10 May 2016 1 5K Report

All of the CTX and P1NP assays performed on the Roche e411 require the patients to fast (10 hours) prior to blood collection. I have seen in recommendation pages that the meals can suppress the bone markers (http://www.racgp.org.au/afp/2013/may/bone-turnover-markers/) but I am unable to find an explanation as to how it masks them.

Jos Wielders

As far as I know, the most important factor is the time of the day, not the nutritional status. Bone markers change from sleeping condition to standing and walking. In general an early morning sample (within a few hours after rising) is preferred.

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