I have a phytochrome protein that takes PCB. The SAR is very low when i coexpress the phytochrome with the pigment producing enzymes. So usually we used to add PCB from external sources. However, our vendor stopped making them. Now i tried fresh transformation, and some other methods hoping to get better PCB levels in vivo. None of them are helping. Any suggestions?
Thank you
Wes Ozarowski
This might help Article Protein X-ray Crystallography and Drug Discovery
This is a review article , but on pages 5,6 it has some excellent tips on how to enhance protein-ligand interaction complexes assuming that you have enough ligand (PCB).
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