We aim to incoporate flow in our tumor model but searching the literature did not yield any clear answers yet. I have found flow rates for HCC between 1 and 16.5 ml/min/g, with the latter being way beyond the total hepatic blood flow. If I am understanding correctly, vascularization in a solid tumor can be increased but total flow is often reduced due to the increased pressure, leading to hypoxia and a necrotic center.
Does anyone know what an adequate flow rate would be for HCC as well as CCC to simulate physiological flow?
Many thanks in advance!
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