In the light of the increasing prevalence of acute myocardial infarction and the increasing age of patients, understanding the relation between age and NT-proBNP concentrations is a key factor in the successful stratification of risk in acute myocardial infarction
Elevated BNP is not a risk factor for AMI. Rather, in patients with AMI/ACS, it is a strong, independent marker for early and late mortality. Physiological basis is probably related to acute/recurrent/chronic myocardial ischemia and left ventricular dysfunction as both are independently related to post AMI/ACS mortality. BNP is elevated in these pathophysiological scenarios.
Dear Anil,
First of all, BNP is clearly associated with incident acute myocardial infarction. In a study published in the Journal of the American Heart Association in November 2013, Matsuzawa et al. demonstrated that BNP is an independent cardiovascular event predictor, hazard ratio 1.019 (CI95% 1.002-1.037, p
Dear all,
Although there is nothing to disagree with Ilir´s very good comments I just want to point out that the question placed by Anil was "the successful stratification of risk in acute myocardial infarction". Thus, as far as I am aware of, in the clinical scenario of AMI BNP provides risk stratification for mortality but not for re-AMI (Bassan R et al, Coron Artery Dis 2009; 20: 143-149). It is my understanding that what Ilir properly points out is that in "normal" individuals who may have sub-clinical coronary artery disease an elevated rest or post-exercise BNP indicates existence of myocardial ischemia. This goes along with the findings of Matsuzawa et al, Kara et al and Foote et al. Very nice discussion, fellows!!
BNP is a marker for heart failure. It is a pepetide secreted when LV end diastolic pressure increases particularly from LV dysfunction. If this dysfuction is caused by ISCHEMIC CARDIOMYOPATHY, then BNP could indicate higer risk for AMI.
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