For a brief overview check out wikipedia for an overview of the NRTL model: https://en.wikipedia.org/wiki/Non-random_two-liquid_model. Perhaps a better option depending on your system is to use UNIQUAC. Most Simulators such as ASPEN have databases that support these models. NRTL0-HOC (Hayden-O'Connell) model is used when you have a non-ideal vapor containing polar or solvating compounds.
NRTL is a non-random two-liquid model used for calculating activity coefficient to take into account non-ideality in the liquid phase. You can get the description in any standard text-book of thermodynamics/phase equilibria.