The HOMA-IR is useful in comparing the degree of insulin resistance between or within groups in a clinical study. It has little relevance in an individual patient due to an number of factors including non-standardised insulin assays and normal pulsatile insulin secretion patterns.

Hello Yougsuo Liu,

The normal HOMA-IR value of healthy human ranges from 1.7-2.0.

For further details, Please, see the linkage below.

http://www.ncbi.nlm.nih.gov/pubmed/20721461

Hi,

The normal reference range for HOMA-IR and HOMA-Beta differs depending on ethnicity and gender.  Here's another article for you:

"Age- and sex-specific reference values for fasting serum insulin levels and insulin resistance/sensitivity indices in healthy Iranian adults: Tehran Lipid and Glucose Study"

http://www.ncbi.nlm.nih.gov/pubmed/24530467

We use a HOMA-IR value > 2 as threshold to determine insulin resistance. Make sure that the patients do not have elevated fasting proinsulin secretion. Proinsulin also lowers glucose and is not detected by the insulin assay. The HOMA-IR would than be too low. In case of intact proinsulin >11 the patient is automatically insulin resistant (Pfützner et al., Diabetes Care 2004).

The HOMA-IR is useful in comparing the degree of insulin resistance between or within groups in a clinical study. It has little relevance in an individual patient due to an number of factors including non-standardised insulin assays and normal pulsatile insulin secretion patterns.

The output of the model is calibrated to give a normal HOMA IR of 1 and its reciprocal is HOMA %S (expressed as a percentage). If IR is > 1,  in subjects with NGT, one cannot conclude that there is necessarily a metabolic defect, although it would not exclude the possibility.

Reference

1. T.M. Wallace, J.C. Levy, D.R. Matthews, Use and abuse of HOMA modeling. Diabetes Care 27, 1487–1495 (2004)

I still do not see any kind of range for HOMA-beta. Is there another name for it?

 Hello

The normal HOMA-IR value of healthy human ranges from 0.5-1.4

Less than 1.0 means you are insulin-sensitive which is optimal.

Above 1.9 indicates early insulin resistance.

Above 2.9 indicates significant insulin resistance.

It is important to determine the healthy HOMA -IR for each ethnic group. This is done by testing a group's Insulin resistance index [HOMA -IR] and comparing it with analytes that reflect inflammation and individual symptoms and pathology. What will be found is that each ethnic group has a different insulin resistance level

Thank for the lighting

Hello Sir Mahboub Sheikhalizadeh

Can you please give reference for the following: The normal HOMA-IR value of healthy human ranges from 0.5-1.4 Less than 1.0 means you are insulin-sensitive which is optimal. Above 1.9 indicates early insulin resistance. Above 2.9 indicates significant insulin resistance.

The 'healthy' insulin resistance range has to be established for every community. See the attached article

There is too much emphasis placed on listing insulin resistance as a disease in its own right, wheras it is siimply physiological varient that, when present, may be a risk factor for diabetes and/or CAD. No-one says it better than Gerald Reaven himself and I quote:

'The primary value of the concept of insulin resistance is that it provides a conceptual framework with which to place a substantial number of apparently unrelated biological events into a pathophysiological construct.' 'It’s primary goal is NOT to make a diagnosis but to increase understanding…'

Gerald Reaven Clinical Chemistry 2005; 51:931-38

Very various levels on HOMA бета in different articles depending on age, sex, investigated population. Roughly it turns out that women till 50 years have more 100, but it is how much more...

Normal values may vary and be different for different ethnic groups and age

There are many surrogate measures for peripheral insulin sensitivity/ resistance& pancreatic B-cell function (B%). Of these is an online calculation formula (HOMA).

Reference range has to be established for each estimate based on different factors like ethnicity, age& BMI.

THANKS

Can you kindly give me the reference for HOMA IR value i couldn't find any supporting citation for my artile

Article Insulin resistance index (HOMA-IR) in the differentiation of...

I hope this article may help you Hira Attique .

Thanks for the help Adil Anwar Bhatti

these are good attempts