Trying to find the relationship between epigenetic and cancer more deeply.
As of my last knowledge update in January 2022, I don't have specific numerical values for the global DNA methylation levels in blood or in breast cancer. The normal global DNA methylation level can vary among individuals, and it can be influenced by various factors such as age, genetics, and environmental exposures.
However, studies have suggested that alterations in DNA methylation patterns can occur in various cancers, including breast cancer. In cancer cells, including breast cancer cells, global DNA hypomethylation (reduced methylation) and regional hypermethylation (increased methylation) of specific genes are common events.
For accurate and up-to-date information on global DNA methylation levels in blood or in the context of breast cancer, I recommend consulting recent scientific literature, medical journals, or reaching out to experts in the field of epigenetics or oncology. Researchers often use advanced techniques, such as genome-wide methylation profiling, to study DNA methylation patterns in specific diseases, including breast cancer.
Dear Samiran,
I will give you some info that I’ve found and know from researches. Both hyper- and hypomethylation are associated with cancer. Multiple studies have investigated DNA methylation in blood-based DNA to develop screening markers for cancer. Studies got heterogeneous results when it comes to this correlation with breast cancer. But two studies reported that hypermethylation of ATM gene was associated with increased risk.
Methylation levels differ from species, regions etc. So it is hard to say what is the normal range. But like colleague said, check the literature and you can find more data that you need.
Sincerely,
Amar, MLT, MSc
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