The best genotoxicity method is the Micronucleus Test.

Thanks dr. Joseph Ayariga

Comet assay

Thanks Thaís Pedrete

The best method for the assessment of genotoxicity is :

For in vitro: Ames assay ( bacterial reverse mutation assay),

For in vitro or in vivo: Micronuclei assay or Chromosomal aberration assay.

I think it will help you.

Thanks Divyansh Sharma

Both micro nucleus assay after induction by Cytochalasin B in cultured lymphocytes and comet assay are excellent methods

Thanks Asha Khanna