It is in detail the repeated daily exposure over years to a powder containing about 50% of titanium dioxide E171, sprayed with compressed air in the breathing zone. What reactions from the lungs can be expected? What about translocation, toxicity, genotoxicity, embryotoxicity of the E171 (nano)particles? Effects of the dispersion state (agglomeration/desagglomeration)? All research I can find for E171 is about oral od dermal route.