The central, top–down approaches of many types of organization—especially the machine organization (bureaucracy)—do not seem suited to the volatility, uncertainty, complexity, and ambiguity (aka VUCA) of 21st century situations. Together with shifting demographic trends and globalization, digital disruption from information and communication technology suggests organizations must transform themselves. What does continuous change demand from organizations? How can organizations promote agility, innovation, and well-being? What initiatives (e.g., coordinating activities, cultivating people, putting human values at the center) might individual and collective leadership animate?