01 September 2013 0 8K Report

Kindly suggest the moderate dose of STZ to induce diabetes in Rattus norvegicus for evaluating antidiabetic activity of herbal plants. We administered STZ with sodium citrate buffer (4.5 pH) with a dosage of 35 mg/kg body weight of rat through i.p at single dose. But the fasting blood glucose level was increased >500 mg/dl on the 3rd day and even some rats (mostly male) were dead 5 days after i.p injection of STZ. So kindly give suggestions

More Saravanan, K's questions See All
Similar questions and discussions